The North West Ambulance Service says the number of 999 calls soared over the Halloween weekend - making it just as busy as New Year's Eve.
There was an increase of 13% this year compared to last year.
There was also a 20% increase in the number of calls about life-threatening emergencies.
Director of Operations, Derek Cartwright said: “The surge in calls was also seen by our neighbouring ambulance trusts so we don’t believe this was unique to the North West but it was disappointing to see so many alcohol and assault related calls.
“Our crews were kept extremely busy dealing with cut hands, head injuries, assault injuries and those who had simply too much alcohol. This ties up our resources for those who urgently need us and unfortunately, there were genuine cases this weekend where people had to wait longer than we would have liked for an ambulance response.
“While we do prioritise resources according to clinical need, we do still have a duty of care to those with head injuries or who are unresponsive regardless as to the reason why but many of these situations can be avoided if people took greater care of themselves and each other.
“We don’t want to stop people having fun but we only have a finite number of resources – including those who answer the calls, and to have phone lines tied up for minor avoidable incidents is frustrating for staff and also puts those people with serious conditions at risk. We are fast approaching the Christmas party season and would like the public to celebrate the festive season responsibly and without injury.”