More than half-a-million pounds worth of resurfacing work is due to begin later this month on the A66 around Keswick.
Highways England will also be refreshing road markings, reflective studs, and fencing over a seven week period starting next Monday.
The first phase will see overnight work carried out between Threlkeld and Scale.
At the end of this month, work will begin between Scales and Mungrisedale.
Highways England project manager Peter Gee said: “This is important work to ensure local people, businesses and tourists can continue to enjoy smooth and safe journeys through this part of the Lake District.
“We’ll be doing most of the work overnight to minimise inconvenience to people.”
Most of the work will be done between 8pm and 6am each night using temporary traffic lights, a 40 mph speed limit and occasional convoy arrangements with drivers being led past the road works at 10mph by a contractor’s vehicle. Some side roads will also be closed overnight but these will be signed locally.
Some daytime working will also take place between Scales and Mungrisedale as a section of the carriageway needs to be reconstructed rather than simply resurfaced.